Iziguli ezinomdlavuza wamaphaphu, Ingabe ukuhlolwa kwe-MRD kuyadingeka?

I-MRD (isifo esincane esisele), noma isifo esincane esisele, iyinombolo encane yamaseli omdlavuza (amaseli omdlavuza angaphenduli noma amelana nokwelashwa) ahlala emzimbeni ngemuva kokwelashwa komdlavuza.
I-MRW ingasetshenziswa njenge-biomarker, ngomphumela omuhle okusho ukuthi izilonda ezisele zisengatholakale ngemuva kokuthola ukwelashwa komdlavuza, kanti amaseli omdlavuza ahlala atholakala ngemuva kokulashwa komdlavuza (akukho amaseli omdlavuza atholakala);
Kuyaziwa ukuthi ukuhlolwa kwe-MRD kudlala indima ebalulekile ekuboneni iziguli ezisezingeni eliphakeme ze-Ingles Lung Leng (NSCLC) engcupheni enkulu yokuphindeka kokuphindaphindwa nasekuqondiseni ukwelashwa okuhlangene ngemuva kokuhlinzwa okuhle.
Izimo lapho i-MND ingafakwa khona:

Okomdlavuza we-auterable esigabeni samaphaphu

1. Ngemuva kokuvuselelwa kabusha kwe-ranceight yesiteji esingewona amaphaphu okungewona ama-Inglerance, ama-MRD positivity abonisa ingozi enkulu yokuphindeka futhi adinga ukuphathwa okulandelayo kokulandela. Ukuqapha i-MRD kunconywa njalo ezinyangeni ezi-3-6;
2. Kunconywa ukwenza izivivinyo zesendlalelo zomtholampilo ezisebenzayo zomdlavuza we-cell ongewona omncane osuselwa ku-MRD, futhi zinikeze ngezinketho zokwelashwa ngokunemba ngokunemba ngangokunokwenzeka;
3. Ncoma ukubheka iqhaza kweNgqomo kuzo zombili izinhlobo zeziguli, gene gene gene gene dele elungile, ngokwehlukana.

Okomdlavuza we-cell ethuthukile wasendaweni

Ukuhlolwa kwe-1.MRD kunconyelwa iziguli ekuxoliseni okuphelele ngemuva kwe-camoredical chemoradietherapy yomdlavuza wamaphaphu we-cell athuthukile, ongasiza ekutholeni i-prognosis futhi wakhe amanye amasu okuthola ukwelashwa;
2
Okomdlavuza we-cell advanced ongemuhle
1. Kukhona ukuntuleka kwezifundo ezifanele ku-MRW kumdlavuza we-cell advanced okungewona omncane;
2. Kunconywe ukuthi i-MRD itholakale ezigulini ezizoxolelwa ngokuphelele ngemuva kokwelashwa okuhlelekile kwama-cell angewona amaphaphu, okungasiza ukwahlulela i-prognosis futhi kwakha amasu okusebenza ngokwelapha;
I-3. Kunconywa ukwenza ucwaningo ngamasu wokwelashwa asuselwa ku-MRD-asuselwa kuMnu. Ukuxolelwa okuphelele kokwelula isikhathi sokuxolelwa isikhathi esiphelele ngangokunokwenzeka ukuze iziguli zikhulise izinzuzo zazo.

Kungabonakala ukuthi ngenxa yokuntuleka kwezifundo ezifanele ekutholeni umdlavuza we-MRD ongeyena omncane, ukusetshenziswa kweNgqongqoshe Ukutholwa ekwelapheni iziguli ezithuthukile ezingezona ezingezincane ezingenamkhawulo.
Eminyakeni yamuva nje, intuthuko ebhekiswe kuyo futhi i-immunotherapy iguqule umbono wezokwelapha iziguli ezine-NSCLC ethuthukisiwe.
Ubufakazi obusafufusa buveza ukuthi ezinye iziguli zithola ukusinda isikhathi eside futhi kulindeleke nokuthi zithole ukuxolelwa okuphelele ngokulingisa. Ngakho-ke, ngaphansi kwesisekelo sokuthi amanye amaqembu eziguli ane-NSCLC athuthukile aqaphele kancane kancane umgomo wokusinda isikhathi eside, ukuqapha izifo ukubhekisisa sekuyindima enkulu yomtholampilo, nokuthi ukuhlolwa kwe-MRD nakho kudlala indima ebalulekile kuyo.