Izindaba - Umbulali Ofihliwe Emhlabeni We-CanineI-hyperthermia Eyingozi

Abanikazi bezilwane ezifuywayo bangase bezwe nge-canine malignant hyperthermia-isifo esibulalayo sofuzo esivame ukwenzeka ngokuzumayo ngemva kokubulala izinzwa. Emgogodleni wayo, ihlotshaniswa eduze nokungajwayelekile ku-Uhlobo lwe-RYR1, futhiukuhlolwa kwe-nucleic acidkuyisihluthulelo sokuhlonza le ngozi yofuzo kusenesikhathi.

Mayelana nephethini yefa, ukuvumelana kwesayensi ukuthi kuyalandelaifa elibusayo le-autosomal elinokungena okungaphelele—okusho ukuthi izinja ezithwele isakhi sofuzo esiguquliwe zingase zingabonisi izimpawu ngaso sonke isikhathi; ukubonakaliswa kuncike kuzibangeli zangaphandle kanye namaleveli wokuvezwa kofuzo.

Namuhla, ake singene sijule ngokuthi lesi sifo senzeka kanjani ngaphansi kwalesi modeli yofuzo nokuthi yiziphi izinto ezibangela ukuba sibangele.

Imfihlakalo Engemuva Kwe-RYR1 Gene Ephuma Ekulawuleni

Ukuze siqonde indlela ye-canine malignant hyperthermia, okokuqala sidinga ukwazi "umsebenzi wosuku" wofuzo lwe-RYR1-usebenza njenge "umlindi weziteshi ze-calcium” Ngaphansi kwezimo ezivamile, lapho inja inyakaza noma idinga ukufinyela kwemisipha, umzila olawulwa isakhi sofuzo se-RYR1 uyavuleka, ukhiphe ama-ion e-calcium agciniwe abe imicu yemisipha ukuze kuqalwe ukufinyela.

yonke inqubo ihlala ihlelekile futhi ilawulwa, ngaphandle kokukhiqiza ukushisa okukhulu.

Kodwa-ke, lapho isakhi sofuzo se-RYR1 siguquka (futhi ifa elibusayo le-autosomal lisho ukuthi ikhophi eyodwa eguquliwe ingaba yi-pathogenic), lo "mgcini-sango" ulahlekelwa ukulawula. Iba nokuzwela ngokweqile futhi ijwayele ukuhlala ivulekile ngaphansi kwezisusa ezithile, okubangela amanani amaningi e-calcium ion ukuthi akhukhule ngokungalawuleki emisipha yemisipha.

Kuleli qophelo, amangqamuzana emisipha awela esimweni sokuthi “ukweqisa”—ngisho nangaphandle kwesibonakaliso sokuncibilika, ziyaqhubeka zibambana nokuncipha okungenamsebenzi. Lokhu kusebenzisa amandla ngokushesha futhi kukhipha amanani amakhulu okushisa. Njengoba izinja zinamandla alinganiselwe okukhipha ukushisa, lapho ukukhiqizwa kokushisa kudlula kude ukubola, izinga lokushisa lomzimba lingakhuphuka ngemizuzu emizuzwini nje (kusuka ku-38-39°C evamile kuye ngaphezu kuka-41°C). Lokhu kukhiqizwa ngokweqile kokushisa okuyingozi yi-calcium eyingozi kakhulu. ukungalingani kubangela ukuqhuma kwezinkinga: i-metabolism ye-muscle ngokweqile ikhiqiza inani elikhulu le-lactic acid ne-creatine kinase, enqwabelana egazini futhi ilimaze izitho ezifana nezinso (i-creatine kinase ingakwazi ukuvala ama-tubules e-renal) kanye nesibindi se-muscle fibers ingase iqhume ngaphansi kokuvinjelwa okuqhubekayo, okubangela i-rhabdomyolysis, i-urinary colored, i-urine-colored, i-urinary colored, i-urinary tract. Izimo ezimbi kakhulu zingase zibe ne-arrhythmia, hypotension, ukuphefumula okusheshayo, nokwehluleka kwezitho eziningi—ngaphandle kokungenelela okuphuthumayo okufika ngesikhathi, izinga lokufa liphezulu kakhulu.

Lapha kufanele sigcizelele ukungena okungaphelele: ezinye izinja zithwala ukuguqulwa kwe-RYR1 kodwa azibonisi izimpawu empilweni yansuku zonke ngoba ukubonakaliswa kofuzo kudinga i-trigger. Kuphela uma kwenzeka izisusa ezithile lapho uguquko luqala ukusebenza futhi imigudu ye-calcium ingalawuleki. Lokhu kuchaza ukuthi kungani abathwali abaningi behlala bephilile impilo yonke uma bengakaze bavezwe yizibangeli-kodwa bangathola ukuqala okungazelelwe uma sekucushiwe.

Izimbangela Ezintathu Eziyinhloko ze-Canine Malignant Hyperthermi

Ukusabela kochungechunge okuchazwe ngenhla kuvame ukuvuswa izigaba ezintathu zezinto:

1. Ama-ejenti Akhethekile Wokubulala Izinzwa (Isicuphi Esiyinhloko)Isizathu esinamandla kakhulu sihilela imithi ethile yokubulala izinzwa—njengehalothane, isoflurane, sevoflurane, kanye neziphumlisi zemisipha eziqeda amandla njenge-succinylcholine. Le mithi isebenzisana ngokuqondile ne-muted RYR1 gene, iqhubekisela phambili ukuqina kweziteshi ze-calcium. Idatha yomtholampilo ibonisa ukuthi cishe i-70% ye-canine eyingozi kakhulu ye-hyperthermia iyenzeka ngesikhathi sokuhlinzwa kusetshenziswa lezi zinzwa, ngokuvamile phakathi kwemizuzu engu-10-30 ngemva kokungeniswa.Ukungena okungaphelele nakho kuboniswa lapha: ezinye izinja ezithwala ukuguqulwa zingase zingaphenduli kule mithi ngenxa yokuhluka kwezakhi zofuzo noma umthamo we-metabolic.

2. Ukushisa Kwemvelo kanye Nomsebenzi WomzimbaIzimo ezishisayo nezinomswakama (isb., izimoto ezivaliwe ezishisayo, ovulandi abachayeke elangeni) zinciphisa ukunqamuka kokushisa. Uma inja yenza umsebenzi oqinile ngaphansi kwezimo ezinjalo, ukushisa kwe-metabolic kukhula kakhulu. Kuhlanganiswe nokungajwayelekile kwe-RYR1, lokhu kungenza ufuzo oluguquliwe lusebenze. Amacala aphinde abikwa ngesikhathi sokuthutha ngenxa yokushisa, ingcindezi, nokunyakaza okuncane.

3. Ukusabela Okukhulu KokucindezelekaUkuhlukumezeka kokuhlinzwa, ukwesaba okungazelelwe (isb., ukujahwa isilwane esikhulu, iziqhumane eziqhumisa phezulu), noma ubuhlungu obukhulu (ukuphuka, ukulimala) kungabangela ukukhuphuka kwe-adrenaline namanye amahomoni okucindezeleka. Lawa mahomoni enza ngokungaqondile isakhi sofuzo se-RYR1 esiguquliwe, abangele ukukhishwa kwe-calcium okungavamile. I-Labrador ethwele ukuguqulwa kwezinguquko yake yaba ne-hyperthermia eyingozi ngenxa yokucindezeleka okuvela engozini yemoto-isibonelo sokungena okungaphelele okubangelwa i-stimu yangaphandle.

Kubalulekile ukuqaphela ukuthi ukuthambekela kuyahlukahluka kuzo zonke izinhlobo.Labrador Retrievers, Golden Retrievers, Beagles, Vizslas, nezinye izinhlobo zinezinga eliphezulu lokuguqulwa kwe-RYR1, kuyilapho izinhlobo ezincane ezifana nama-Chihuahuas nama-Pomeranians zinezigameko ezimbalwa ezibikiwe. Iminyaka yobudala nayo idlala indima—izinja ezisencane (ezineminyaka engu-1-3 ubudala) zine-metabolism yemisipha esebenza kakhulu, okuzenza zibe sengcupheni yokucupha kunezinja ezindala.

Ukuhlolwa Kwezakhi Zofuzo: Ukuvimbela Ngaphambi Kokuvela Kwezimpawu

Kubanikazi bezilwane ezifuywayo, ukuqonda lezi zindlela kanye nezimbangela kuvumela ukuvimbela okungcono:

Uma inja yakho ingeye-auhlobo olusengozini enkulunoma unayo aumlando womndeni(ifa elikhulu lisho ukuthi izihlobo zingase zithwale ukuguqulwa okufanayo), njalo yazisa odokotela bezilwane ngaphambi kokubulala izinzwa. Bangakhetha imithi ephephile (isb, i-propofol, i-diazepam) futhi balungise amathuluzi okupholisa (amaphakethe eqhwa, izingubo zokulala zokupholisa) kanye nemithi yezimo eziphuthumayo.

Gwemaukuzivocavoca okukhulungesikhathi sezulu esishisayo.

Nciphisaizimo eziphezulu zokucindezelekaukunciphisa ukuchayeka kwe-trigger.

Inani lokuhlolwa kwe-nucleic acidngoba i-canine malignant hyperthermia ilele ekukhombeni ukuthi inja yakho iphethe ukuguqulwa kwe-RYR1. Ngokungafani nokuhlolwa kwegciwane, okuthola ukutheleleka, lolu hlobo lokuhlola lwembula ingozi yofuzo. Ngisho noma inja ingenayo i-symptomatic ngenxa yokungena okungaphelele, ukwazi isimo sayo sofuzo kuvumela abanikazi ukuthi balungise ukunakekelwa kanye nezinqumo zezokwelapha ukuze bagweme izimbangela-ukugcina izilwane ezifuywayo ziphephile kulesi simo esisongela ukuphila.

Isikhathi sokuthumela: Nov-13-2025